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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAPPA2
All Species:
5.76
Human Site:
S217
Identified Species:
15.83
UniProt:
Q9BXP8
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BXP8
NP_064714.2
1791
198539
S217
Q
G
D
S
G
I
S
S
H
F
Q
P
W
P
K
Chimpanzee
Pan troglodytes
XP_514020
1791
198653
S217
Q
G
D
S
G
I
S
S
H
F
Q
P
W
P
K
Rhesus Macaque
Macaca mulatta
XP_001095160
1573
175281
H94
W
W
G
E
W
S
T
H
L
E
E
E
S
E
K
Dog
Lupus familis
XP_537179
1778
195855
W208
G
D
P
G
V
S
P
W
H
F
Q
S
W
P
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4K8
1624
181300
S145
Y
D
K
C
S
Y
T
S
R
D
R
G
W
V
M
Rat
Rattus norvegicus
XP_001073420
1788
198541
Q217
R
D
P
Q
N
T
P
Q
D
V
Q
L
W
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_426627
1551
171156
V72
R
L
P
E
L
C
V
V
A
I
G
V
F
D
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695417
1759
195473
K214
N
E
E
V
I
P
E
K
S
Y
N
H
H
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_795597
1601
177169
K122
E
S
D
L
L
L
Y
K
R
I
G
D
A
G
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
39.7
81.7
N.A.
43.6
79.4
N.A.
N.A.
57.9
N.A.
48
N.A.
N.A.
N.A.
N.A.
33.6
Protein Similarity:
100
99.7
56.3
89
N.A.
60
87.2
N.A.
N.A.
68.2
N.A.
63.8
N.A.
N.A.
N.A.
N.A.
49
P-Site Identity:
100
100
6.6
40
N.A.
13.3
26.6
N.A.
N.A.
0
N.A.
0
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
20
40
N.A.
26.6
33.3
N.A.
N.A.
13.3
N.A.
20
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
12
0
0
0
12
0
0
% A
% Cys:
0
0
0
12
0
12
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
34
34
0
0
0
0
0
12
12
0
12
0
12
0
% D
% Glu:
12
12
12
23
0
0
12
0
0
12
12
12
0
12
12
% E
% Phe:
0
0
0
0
0
0
0
0
0
34
0
0
12
0
12
% F
% Gly:
12
23
12
12
23
0
0
0
0
0
23
12
0
12
0
% G
% His:
0
0
0
0
0
0
0
12
34
0
0
12
12
0
0
% H
% Ile:
0
0
0
0
12
23
0
0
0
23
0
0
0
0
0
% I
% Lys:
0
0
12
0
0
0
0
23
0
0
0
0
0
0
56
% K
% Leu:
0
12
0
12
23
12
0
0
12
0
0
12
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% M
% Asn:
12
0
0
0
12
0
0
0
0
0
12
0
0
0
12
% N
% Pro:
0
0
34
0
0
12
23
0
0
0
0
23
0
45
0
% P
% Gln:
23
0
0
12
0
0
0
12
0
0
45
0
0
0
0
% Q
% Arg:
23
0
0
0
0
0
0
0
23
0
12
0
0
0
0
% R
% Ser:
0
12
0
23
12
23
23
34
12
0
0
12
12
0
0
% S
% Thr:
0
0
0
0
0
12
23
0
0
0
0
0
0
12
0
% T
% Val:
0
0
0
12
12
0
12
12
0
12
0
12
0
12
0
% V
% Trp:
12
12
0
0
12
0
0
12
0
0
0
0
56
0
0
% W
% Tyr:
12
0
0
0
0
12
12
0
0
12
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _